Clinical trials are the foundation of medical progress, driving the discovery of new treatments and improving patient outcomes. Highlands Oncology has been actively involved in clinical research for more than 26 years, conducting numerous studies in both oncology and hematology. Through these trials, new experimental medications—or innovative ways of using existing therapies—are compared to current standards of care. This process helps advance cancer treatment for patients locally and around the world. Each clinical trial follows strict eligibility criteria designed to ensure patient safety. Clinical trials typically progress through four phases of development:
Phase I: Determines safe dosage levels and evaluates safety
Phase II: Further assesses safety and begins to evaluate effectiveness
Phase III: Compares the new therapy to standard treatments
Phase IV: Studies the long-term safety and effectiveness of FDA-approved treatments
Highlands Oncology is proud to be the only community-based Phase I oncology clinical trial center in Arkansas, offering patients access to the newest and most innovative cancer therapies close to home.
Cancer research is constantly evolving, and new treatments emerge every year. Our Research Department ensures that Highlands Oncology remains at the forefront of medical innovation through continued participation in clinical trials. We are committed to providing every patient with as many treatment options as possible. Only you and your physician can decide if a clinical trial is right for you. To explore our currently enrolling studies, please visit our Clinical Trials page. For more information about clinical trials in general, visit clinicaltrials.gov.
J. Thaddeus Beck, Research Medical Director
Dr. Thad Beck expressed his desire to be involved in cancer clinical trials from the beginning of his career. His intellectual curiosity and desire to make a difference in patient outcomes have been a driving force in everything he does. As a founding member of Highlands Oncology, Dr. Beck sought to change the face of oncology in our community so that patients did not have to leave their hometown to receive cutting-edge cancer care.
Fortunately, Dr. Beck was persuaded to bring this energy and dream to Northwest Arkansas, where, as Medical Director he created from the ground up, one of the largest and most successful community-based clinical trial programs in the country. At any given time, he oversees over 140 active clinical trials, 30 providers, and over 50 clinical trials staff.
Even with this load, Dr. Beck still takes the time to sit with his patients, draw up a plan, and ensure that they understand and are prepared for the journey ahead.
He uses his exceptional expertise and years of experience to hand pick clinical trials he believes will be relevant and helpful for the patients in this community.
Frequently we have patients who will consider other large institutions or academic centers looking for an innovative clinical trial only to be redirected back home to Highlands where we have the exact same trial. This is a testament to the proficiency and expertise of Dr. Beck and his team.
Dr. Beck cares for his research team like he cares for his patients. He is always eager to answer questions about patients, oncology protocols, and treatments. He loves to teach those who enjoy learning to help them understand the significance of these trials in the future of oncology patient care.
Today, patients in Northwest Arkansas can participate in first-line clinical trials. Additionally, Highlands receives patients from around the world who travel here to participate in clinical trials where Phase I – III therapies are available.
“Such a pleasant experience. I would give all of them 100 stars.”
HIGHLANDS PATIENT
Contact Clinical trials
For questions or more information, please contact our Clinical Trials Team:
Referring providers who would like to explore clinical trial opportunities for their patients are encouraged to submit a referral using the button below. A member of our Clinical Research team will evaluate eligibility and follow up as appropriate.
Adcendo/ADCE-T02-001/First-in-Human, Phase 1 Study of ADCE-T02, a Tissue Factor Targeted Antibody-Drug Conjugate, in Patients with Advanced Solid Tumors
SOLID TUMORS
10/28/2026
5646
Pfizer/C6631001/A PHASE 1 DOSE ESCALATION AND EXPANSION STUDY TO EVALUATE SAFETY, TOLERABILITY, PHARMACOKINETICS, PHARMACODYNAMICS, AND ANTI-TUMOR ACTIVITY OF PF-08165784 MONOTHERAPY AND COMBINATIONS IN PARTICIPANTS WITH PIK3CA-MUTATED ADVANCED OR METASTATIC SOLID TUMORS
SOLID TUMORS
10/22/2026
5824
Nurix/NX-5948-306/A Phase 3, Randomized, Open-label, Multicenter Study of NX-5948 Versus Pirtobrutinib in Relapsed/Refractory (R/R) Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL)
Lymphoma
10/14/2026
5812
Stemline/STML-ELA-0422/Elacestrant versus Standard Endocrine Therapy in Women and Men with Node-positive, Estrogen Receptor-positive, HER2-negative, Early Breast Cancer with High Risk of Recurrence - A Global, Multicenter, Randomized, Open-label Phase 3 Study (ELEGANT)
BREAST
10/13/2026
5740
Daiichi Sankyo/DS3939-156/A Phase 1b/2, Multicenter, 2-Part, Open-label Trial to Evaluate DS-3939a in Participants with Solid Tumors
SOLID TUMORS
10/13/2026
5825
Johnson and Johnson/78278343PCR3003/A Phase 3 Randomized, Open-label Study of JNJ-78278343, a T Cell-redirecting agent targeting Human Kallikrein 2, with Docetaxel Versus Docetaxel for Metastatic Castration-Resistant Prostate Cancer
PROSTATE
10/12/2026
5811
Henlius USA Inc./HLX15-SC-NDMM-001/A Randomized, Double-blind, Parallel-controlled Phase I Study to Compare the Pharmacokinetic Characteristics, Safety, Tolerability, and Immunogenicity of HLX15-SC with DARZALEX FASPRO® in Combination with Lenalidomide-Dexamethasone (Rd) in Transplant-ineligible Patients with Newly Diagnosed Multiple Myeloma
MULTIPLE MYELOMA
10/11/2026
5696
Henlius USA Inc./HLX18-MRST001/A Multicenter, Randomized, Double-Blind, Parallel-Controlled Phase I Clinical Study to Evaluate the Pharmacokinetic Profile, Efficacy, Safety and Immunogenicity of HLX18 vs. OPDIVO® (US-sourced OPDIVO®) in Multiple Resected Solid Tumors
SOLID TUMORS
10/05/2026
5826
Bristol-Myers Squibb/CA239-0004/Randomized, Double-Blind, Phase 3 Trial of Adagrasib plus Pembrolizumab plus Chemotherapy vs. Placebo plus Pembrolizumab plus Chemotherapy in Participants with Previously Untreated, Locally Advanced or Metastatic Non-squamous Non-small Cell Lung Cancer with KRAS G12C Mutation
LUNG - Non Small Cell Cancer (NSCLC)
09/30/2026
5799
AstraZeneca/D972DC00001/EvoPar-Prostate05: Phase III Double-blinded Study of Saruparib + ARPI in Patients with Metastatic Hormone-Sensitive Prostate Cancer Previously Treated with Docetaxel or PSMA-Directed 177Lutetium-Containing Therapy without Disease Progression and PSA ≥0.2 ng/mL
PROSTATE
09/25/2026
5781
NRG Oncology/NRG-GU014/Testing the Addition of the Immunotherapy Drug, Pembrolizumab, to Radiation Therapy Compared to the Usual Chemotherapy Treatment During Radiation Therapy for Bladder Cancer, PARRC Trial
Urothelial
09/21/2026
5782
Systimmune/BL-M14D1-LC-301/A Phase 3 Open-Label, Randomized Controlled Trial of BL-M14D1 and Atezolizumab vs. Standard of Care Therapy in Patients with First-Line Extensive-Stage Small Cell Lung Cancer
LUNG - Small Cell Cancer (SCLC)
09/17/2026
5759
Merck/MK-1026-010/A Phase 3, Open-label, Randomized Study to Compare the Efficacy and Safety of Nemtabrutinib (MK-1026) Plus Venetoclax Versus Venetoclax Plus Rituximab in Participants With Relapsed/Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma Following at Least 1 Prior Therapy (BELLWAVE-010)
Lymphoma
09/01/2026
5711
Ascentage/APG2575CG301/A Phase 3, Open Label, Randomized, Multicenter Study of Lisaftoclax (APG-2575) in Previously Treated Patients with Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma
Lymphoma
08/24/2026
5647
Daiichi Sankyo/CSNDSI02/Retrospective Chart Review to Characterize Real-World Use, Clinical Outcomes, and Safety of Datopotamab Deruxtecan (Dato-Dxd) in EGFR-Mutated NSCLC Following FDA Approval (June 23, 2025), Including Treatment Patterns and Outcomes Among Participants Eligible for Dato-Dxd
LUNG - Non Small Cell Cancer (NSCLC)
08/20/2026
5674
NRG Oncology/NRG-GY035/Testing the Addition of an Antiangiogenic Drug (Bevacizumab) to Chemotherapy (Carboplatin and Paclitaxel) Combined With Immunotherapy (Pembrolizumab) for pMMR, TP53 Mutated Endometrial Cancer
Endometrial
08/17/2026
5715
NRG Oncology/NRG-GY037/Induction Pembrolizumab and Chemotherapy Followed by Pembrolizumab Before Chemoradiation and Pembrolizumab Maintenance Compared to Standard Chemoradiation With Pembrolizumab Followed by Pembrolizumab Maintenance in High-Risk Cervical Cancer
Cervical
08/17/2026
5717
Novartis/CVAY736Q1US01/An exploratory study to evaluate the safety and tolerability of investigator's choice thrombopoietin receptor agonist (TPO-RA) with ianalumab (VAY736) in patients with primary immune thrombocytopenia (ITP) previously treated with at least one line of therapy
ITP
07/31/2026
5675
AbbVie/M24-560/AndroMETa-CRC-560: An Open-Label, Randomized, Controlled, Global Phase 3 Study Comparing Telisotuzumab Adizutecan (ABBV-400) plus Bevacizumab to LONSURF (Trifluridine and Tipiracil) plus Bevacizumab in Subjects with Refractory Metastatic Colorectal Cancer
COLORECTAL
07/30/2026
5706
Henlius USA Inc./HLX43-NSCLC201/An Open-label, Multi-center, Global Phase II Clinical Study to Evaluate the Efficacy and Safety of HLX43 (Anti-PD-L1 ADC) in Subjects with Advanced Non-small Cell Lung Cancer (NSCLC)
LUNG - Non Small Cell Cancer (NSCLC)
07/28/2026
5697
AstraZeneca/D516KC00001/A Phase III, Open Label, Sponsor-Blind, Randomized Study of Dato DXd With or Without Osimertinib Versus Platinum-Based Doublet Chemotherapy for Patients with EGFR-mutated Locally Advanced or Metastatic Non-Small Cell Lung Cancer whose Disease has Progressed on Prior Osimertinib Treatment (TROPION-Lung15)
LUNG - Non Small Cell Cancer (NSCLC)
07/24/2026
5676
Natera/25-092-NCP/Bespoke Pan Cancer
SOLID TUMORS
07/22/2026
5630
SWOG/S2427/Single Arm Phase II Study of Bladder Preservation with Immunoradiotherapy after a Clinically Meaningful Response to Neoadjuvant Therapy in Patients with Muscle Invasive Bladder Cancer (BRIGHT)
Urothelial
07/17/2026
5733
AstraZeneca/D9670C00001 DESTINY-Breast 06/A Phase 3, Randomized, Multi-center, Open-label Study of Trastuzumab Deruxtecan (T-DXd) Versus Investigator’s Choice Chemotherapy in HER2-low, Hormone Receptor Positive Breast Cancer Patients whose Disease has Progressed on Endocrine Therapy in the Metastatic Setting (DESTINY-Breast06)
BREAST
06/30/2026
5689
Bristol-Myers Squibb/CA266-0003/A Blinded, Randomized Phase 2/3 Study of Pumitamigin Combination with Chemotherapy Versus Bevacizumab in Combination with Chemotherapy in Participants with Previously Untreated, Unresectable, or Metastatic Colorectal Cancer
COLORECTAL
06/19/2026
5669
SWOG/S1418/A RANDOMIZED, PHASE III TRIAL TO EVALUATE THE EFFICACY AND SAFETY OF PEMBROLIZUMAB (MK-3475) AS ADJUVANT THERAPY FOR TRIPLE RECEPTOR-NEGATIVE BREAST CANCER WITH ≥ 1 CM RESIDUAL INVASIVE CANCER OR POSITIVE LYMPH NODES (ypN1mi, ypN1-3) AFTER NEOADJUVANT CHEMOTHERAPY
BREAST
06/18/2026
5725
SWOG/S2419/Phase III Double Blinded Trial of Immune-Based Therapy with a LiveBIOtherapeutic CBM588 or Placebo forFRONTline Therapy of Advanced Clear Cell Renal Cell Carcinoma (BIOFRONT Trial)
Renal
06/16/2026
5732
ECOG/E1609/A Phase III Randomized Study of Adjuvant Ipilimumab Anti-CTLA4 Therapy Versus High Dose Interferon a-2b for Resected High Risk Melanoma
MELANOMA
06/02/2026
5692
Johnson and Johnson/79635322MMY3002/Phase 3 Randomized Study Comparing JNJ-79635322 versus Teclistamab in Participants with Relapsed or Refractory Multiple Myeloma who Have Received 1-3 Prior Lines of Therapy
MULTIPLE MYELOMA
05/22/2026
5638
ImmunityBio/SP-402/N-803 In Combination With Low-Dose Cyclophosphamide and Ivosidenib For Advanced IDH1-Mutant Cholangiocarcinoma
SOLID TUMORS
05/11/2026
5737
UA-F/Breast Biopsies/Investigating relevant biomarkers of breast cancer core biopsies to predict tumor response to chemotherapy using spectroscopy and non-linear imaging
BREAST
05/05/2026
5653
Pfizer/C4551002/An Interventional, Open-Label, Randomized, Multicenter, Phase 3 Study of PF-07248144 Plus Fulvestrant Compared to Investigators Choice of Therapy in Adult Participants with Hormone Receptor-Positive, HER2-Negative Advanced/Metastatic Breast Cancer Whose Disease Progressed After Prior CDK4/6 Inhibitor-based Therapy Study
BREAST
05/05/2026
5657
Bristol-Myers Squibb/CA240-0030/A Randomized Phase 2-3 Study Comparing BMS-986504 in Combination with Nab-paclitaxel and Gemcitabine versus Placebo in Combination with Nab-paclitaxel and Gemcitabine in Participants with Untreated Metastatic Pancreatic Ductal Adenocarcinoma Harboring Homozygous MTAP Deletion
Pancreatic
05/05/2026
5668
Personalis/01-PS-001/Breast Cancer-Minimal/Molecular Residual Disease Detection and Therapy Monitoring in Patients with Early Stage TNBC-Phase I (B-STRONGER-I)
BREAST
05/01/2026
5629
Eli Lilly/J3M-MC-JZQB/A Global Pivotal Study in Patients with KRAS G12C-Mutant, Locally Advanced or Metastatic Non-Small Cell Lung Cancer Comparing First-Line Treatment of Pembrolizumab and LY3537982 vs Pembrolizumab and Placebo in those with PD-L1 ≥ 50% or Pembrolizumab, Pemetrexed, Platinum Chemotherapy and LY3537982 vs Pembrolizumab, Pemetrexed, Platinum Chemotherapy and Placebo regardless of PD-L1 Expression
LUNG - Non Small Cell Cancer (NSCLC)
04/24/2026
5702
ImmunityBio/ResQ201A-NSCLC/RANDOMIZED, OPEN-LABEL, PHASE 3 CLINICAL TRIAL OF N-803 PLUS TISLELIZUMAB AND DOCETAXEL VERSUS DOCETAXEL MONOTHERAPY IN PARTICIPANTS WITH ADVANCED OR METASTATIC NON-SMALL CELL LUNG CANCER WHO HAVE ACQUIRED RESISTANCE TO IMMUNE CHECKPOINT INHIBITOR THERAPY
LUNG - Non Small Cell Cancer (NSCLC)
04/22/2026
5721
Pfizer/C6461006/AN INTERVENTIONAL PHASE 1B/2, OPEN-LABEL STUDY TO INVESTIGATE THE TOLERABILITY, ANTITUMOR ACTIVITY, AND PHARMACOKINETICS OF PF-08634404 MONOTHERAPY OR IN COMBINATION WITH ENFORTUMAB VEDOTIN IN ADULT PARTICIPANTS WITH LOCALLY ADVANCED OR METASTATIC UROTHELIAL CANCER
Urothelial
04/10/2026
5662
Black Diamond Therapeutics/BDTX-1535-201/A Phase 2 Randomized, Multicenter Study to Evaluate the Efficacy and Safety of Silevertinib, an Oral EGFR Inhibitor, in Combination with Temozolomide in Patients with Newly Diagnosed Glioblastoma with Unmethylated MGMT Promoter and EGFRvIII
Glioblastoma
03/26/2026
5649
Adcendo/ADCE-B05-001/A First-in-Human, Phase 1a/1b, Open-Label Multicenter Study to Assess the Safety, Tolerability, Pharmacokinetics, Immunogenicity, and Antitumor Activity of the Antibody Drug Conjugate ADCE-B05 in Patients with Advanced Solid Tumors
SOLID TUMORS
03/23/2026
5645
Pfizer/C4391024/AN INTERVENTIONAL, OPEN-LABEL, RANDOMIZED, MULTICENTER PHASE 3 STUDY OF PF-07220060 PLUS LETROZOLE COMPARED TO CDK4/6 INHIBITOR PLUS LETROZOLE IN PARTICIPANTS OVER 18 YEARS WITH HORMONE RECEPTOR (HR)-POSITIVE, HER2-NEGATIVE ADVANCED/METASTATIC BREAST CANCER WHO HAVE NOT RECEIVED ANY PRIOR SYSTEMIC ANTI-CANCER TREATMENT FOR ADVANCED/METASTATIC DISEASE
BREAST
03/16/2026
5656
SWOG/S2433/Randomized Phase II Study of Second-Line Chemotherapy with or Without Panitumumab for Locally Advanced or Metastatic KRAS/ BRAFV600E Wild-Type Pancreatic Ductal Adenocarcinoma
Pancreatic
03/16/2026
5734
Bristol-Myers Squibb/CA057-1070/Intermediate-size Patient Population Expanded Access Program, Expanded Access Program for Mezigdomide (in combination with Carfilzomib and Dexamethasone or Bortezomib and Dexamethasone), For Patients with Relapsed/Refractory Multiple Myeloma (RRMM)
MULTIPLE MYELOMA
03/12/2026
5665
Hidalga Technologies/2507367/AI-Driven Platform for Prior Authorization Automation and Workflow Optimization in Oncology Specialty Healthcare
SOLID TUMORS
02/17/2026
5635
UAMS/299313/Training Data and Validation for LCS-DINO, a Self-Supervised AI Model for Lung Cancer Screening
SOLID TUMORS
02/13/2026
5633
Pfizer/C6461003/AN INTERVENTIONAL PHASE 3, DOUBLE-BLIND, RANDOMIZED, STUDY EVALUATING PF-08634404 IN COMBINATION WITH CHEMOTHERAPY VERSUS BEVACIZUMAB IN TREATMENT NAÏVE PARTICIPANTS WITH METASTATIC COLORECTAL CANCER
COLORECTAL
02/10/2026
5660
AbbVie/M24-108/A Multicenter, Phase 1b, Open-label Study to Evaluate Dose Optimization Measures and Safety of ABBV-383 in Subjects with Relapsed or Refractory Multiple Myeloma
MULTIPLE MYELOMA
02/09/2026
5705
Pfizer/C6461020/AN OPEN-LABEL PHASE 1B/2 STUDY TO INVESTIGATE PF-08634404 IN COMBINATION WITH DIFFERENT ANTICANCER AGENTS IN ADVANCED SOLID TUMORS
SOLID TUMORS
02/05/2026
5664
Pfizer/C5851005/A RANDOMIZED, PHASE 3, OPEN-LABEL STUDY TO EVALUATE PF-08046054/SGN-PDL1V VERSUS DOCETAXEL IN ADULT PARTICIPANTS WITH PREVIOUSLY-TREATED PROGRAMMED CELL DEATH LIGAND 1 (PD-L1) POSITIVE NON-SMALL-CELL LUNG CANCER (NSCLC)
LUNG - Non Small Cell Cancer (NSCLC)
01/30/2026
5658
Johnson and Johnson/61186372COR3001/A Randomized, Open-label Phase 3 Study of Amivantamab and mFOLFOX6 or FOLFIRI Versus Cetuximab and mFOLFOX6 or FOLFIRI as First-line Treatment in Participants With KRAS/NRAS and BRAF Wild-type Unresectable or Metastatic Left-sided Colorectal Cancer
COLORECTAL
01/28/2026
5636
Johnson and Johnson/61186372COR3002/A Randomized, Open-label Phase 3 Study of Amivantamab + FOLFIRI Versus Cetuximab/Bevacizumab + FOLFIRI in Participants With KRAS/NRAS and BRAF Wild-type Recurrent, Unresectable or Metastatic Colorectal Cancer Who Have Received Prior Chemotherapy
COLORECTAL
01/28/2026
5637
BostonGene/BGER001/A Prospective Study of Comprehensive Molecular Testing in Advanced Cancer Patients in the Community Setting
SOLID TUMORS
01/27/2026
5650
AstraZeneca/D8532C00001 SERENA 4/A Randomised, Multicentre, Double-Blind, Phase III Study of AZD9833 (an Oral SERD) plus Palbociclib versus Anastrozole plus Palbociclib for the Treatment of Patients with Estrogen Receptor-Positive, HER2-Negative Advanced Breast Cancer Who Have Not Received Any Systemic Treatment for Advanced Disease
BREAST
01/16/2026
5686
ImmunityBio/SP-269/N-803 plus SACITUZUMAB GOVITECAN FOR TRIPLE NEGATIVE BREAST CANCER WITH BRAIN METASTASES
BREAST
01/14/2026
5736
Pfizer/C6461008/AN INTERVENTIONAL 1B/2 OPEN-LABEL STUDY TO INVESTIGATE SAFETY AND EFFICACY OF PF-08634404 (SSGJ-707) MONOTHERAPY OR IN COMBINATION WITH OTHER AGENTS IN ADULT PARTICIPANTS WITH PREVIOUSLY UNTREATED LOCALLY ADVANCED OR METASTATIC RENAL CELL CARCINOMA
Renal
01/12/2026
5663
Pfizer/C6461001/AN INTERVENTIONAL PHASE 3, DOUBLE-BLIND, RANDOMIZED STUDY TO EVALUATE EFFICACY AND SAFETY OF PF-08634404 IN COMBINATION WITH CHEMOTHERAPY VERSUS PEMBROLIZUMAB IN COMBINATION WITH CHEMOTHERAPY IN ADULT PARTICIPANTS WITH LOCALLY ADVANCED OR METASTATIC NON-SMALL CELL LUNG CANCER
LUNG - Non Small Cell Cancer (NSCLC)
12/23/2025
5659
Daiichi Sankyo/DS7300-188/A Phase 3, Multicenter, Randomized, Open-label Study of Ifinatamab Deruxtecan (I-DXd), a B7-H3 Antibody Drug Conjugate (ADC), Versus Treatment of Physicians Choice (TPC) in Subjects with Relapsed Small Cell Lung Cancer (SCLC) (IDeate-2)
LUNG - Small Cell Cancer (SCLC)
12/23/2025
5691
Paradigm/PHPE-07-002/Molecular Residual Disease in Solid Tumors: A Prospective Study to Collect Clinical Data and Biospecimens to Support Discovery and Development of Cancer Biomarkers
SOLID TUMORS
12/23/2025
5720
Pfizer/C6461004/A PHASE 2/3 DOSE EXPANSION FOLLOWED BY A RANDOMIZED, DOUBLE-BLIND STUDY OF PF 08634404 VS. ATEZOLIZUMAB IN COMBINATION WITH CHEMOTHERAPY IN PATIENTS WITH EXTENSIVE-STAGE SMALL CELL LUNG CANCER
LUNG - Small Cell Cancer (SCLC)
12/17/2025
5661
AbbVie/M25-713/A Phase 2/3 Study of Telisotuzumab Adizutecan Versus SOC After Progression on a Third-Generation EGFR TKI - AndroMETa-Lung-713
LUNG - Non Small Cell Cancer (NSCLC)
12/02/2025
5707
AstraZeneca/D798AC00001/A Phase III, Two-Arm, Parallel, Randomized, Multi-Center,Open-Label, Global Study to Determine the Efficacy of Volrustomig (MEDI5752) Plus Chemotherapy Versus Pembrolizumab Plus Chemotherapy for First-Line Treatment of Patients with Metastatic Non-Small Cell Lung Cancer (mNSCLC) (eVOLVE-Lung02)
LUNG - Non Small Cell Cancer (NSCLC)
11/14/2025
5678
Eli Lilly/J2J-MC-JZLH EMBER-4/EMBER-4: A Randomized, Open-Label, Phase 3 Study of Adjuvant Imlunestrant vs Standard Adjuvant Endocrine Therapy in Patients who have Previously Received 2 to 5 years of Adjuvant Endocrine Therapy for ER+, HER2- Early Breast Cancer with an Increased Risk of Recurrence
BREAST
11/13/2025
5701
BioNTech/BNT327-05/A clinical study to test if the investigational treatment, BNT327, given with chemotherapy is potentially beneficial in patients with previously untreated locally recurrent or metastatic triple-negative breast cancer
BREAST
11/11/2025
5652
Eli Lilly/J6M-MC-JSGD/A Phase 3, Randomized, Double-blind, Placebo-controlled Study of LY4064809 Combined with a CDK4/6 inhibitor and Endocrine Therapy in Adults with HR+, HER2- Advanced Breast Cancer with a PIK3CA Mutation who received no prior treatment for Advanced Breast Cancer (PIKALO-2)
BREAST
11/11/2025
5704
Stemline/MEN2501-01/A Phase 1, First-in-Human Study of MEN2501, a KIF18A Inhibitor, in Participants with Ovarian Cancer
Ovarian
11/10/2025
5709
Exelixis/XB371-101/A Dose Escalation and Expansion Study of XB371 Administered in Participants with locally advanced or metastatic solid tumors
SOLID TUMORS
10/28/2025
5743
Genentech/ML45219/PHASE II, OPEN-LABEL, PROSPECTIVE SINGLE-ARM, MULTI-CENTER CLINICAL TRIAL TO EVALUATE IF ADDING VENETOCLAX TO PATIENTS ON COVALENT BTKI-MONOTHERAPY FOR 1L CLL CAN ACHIEVE DEEP DURABLE REMISSIONS (BY uMRD 10-4) TO ALLOW OFF-TREATMENT PERIOD
Leukemia
10/20/2025
5713
NRG Oncology/NRG-GY036/A Phase III Trial of One vs. Two Years of Maintenance Olaparib, with or Without Bevacizumab, in Patients with BRCA1/2 Mutated or Homologous Recombination Deficient (HRD+) Ovarian Cancer Following Response to First Line Platinum-Based Chemotherapy
Ovarian
10/14/2025
5716
Henlius USA Inc./HLX10-005-SCLC301-E/A Randomized, Open-label Study of HLX10 plus Chemotherapy (CarboplatinEtoposide) in comparison with Atezolizumab plus Chemotherapy in Previously Untreated US Patients with Extensive Stage Small Cell Lung Cancer (ES-SCLC)
LUNG - Small Cell Cancer (SCLC)
10/13/2025
5694
SWOG/S2308/Randomized Phase III Study of Mosunetuzumab vs. Rituximab for Low Tumor Burden Follicular Lymphoma
Lymphoma
09/30/2025
5730
SWOG/S2212/Shorter Chemo-Immunotherapy Without Anthracycline Drugs for Early-Stage Triple Negative Breast Cancer
BREAST
09/24/2025
5728
Pfizer/C2321008/A PHASE 3, RANDOMIZED, DOUBLE BLIND, PLACEBO-CONTROLLED STUDY OF MEVROMETOSTAT (PF-06821497) WITH ENZALUTAMIDE IN METASTATIC CASTRATION-SENSITIVE PROSTATE CANCER (MEVPRO-3)
PROSTATE
09/22/2025
5655
AstraZeneca/D9520C00001/A Modular Phase I/IIa, Open-label, Multi-centre Study to Assess the Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of AZD0516 as Monotherapy and in Combination with Anti-cancer Agents in Participants with Metastatic Prostate Cancer (SEACLIFF)
PROSTATE
09/17/2025
5688
Bristol-Myers Squibb/CA240-0029/A Randomized Phase 2/3 Study of BMS-986504 in Combination with Pembrolizumab and Chemotherapy Versus Placebo Plus Pembrolizumab and Chemotherapy in First-line Metastatic Non-small Cell Lung Cancer Participants with Homozygous MTAP Deletion
LUNG - Non Small Cell Cancer (NSCLC)
09/08/2025
5667
Ovation.io/Ovation-23-001/Collection of Biological Specimens and Associated Health Information for Secondary Research
SOLID TUMORS
09/04/2025
5719
AstraZeneca/D926QC00001/Phase III, Open-label, Randomised Study of Neoadjuvant Datopotamab Deruxtecan (Dato-DXd) Plus Durvalumab Followed by Adjuvant Durvalumab With or Without Chemotherapy Versus Neoadjuvant Pembrolizumab Plus Chemotherapy Followed by Adjuvant Pembrolizumab With or Without Chemotherapy for the Treatment of Adult Patients with Untreated Triple-Negative or Hormone Receptor-low/HER2-negative Breast Cancer
BREAST
07/18/2025
5680
NRG Oncology/NRG-GY028/A Phase IB and Randomized Phase II Trial of Megestrol Acetate with or Without Ipatasertib in Recurrent or Metastatic Endometrioid Endometrial Cancer
Endometrial
07/01/2025
5714
SWOG/S2114/A Randomized Phase II trial of consolidation therapy following CD19 CAR T-cell treatment for Relapsed/Refractory Diffuse Large B-cell Lymphoma or Grade IIIB Follicular Lymphoma
Lymphoma
07/01/2025
5726
OncoC4/BiPAVE-001/Safety, Pharmacokinetics, and Efficacy of AI-081, a Bispecific Antibody for PD-1 and VEGF, in Advanced Solid Tumors
SOLID TUMORS
06/26/2025
5651
Eli Lilly/J3M-MC-JZQH/A Phase 3, Multi-center, Double-blind, 2-part Study in Participants with KRAS G12C-Mutant, Non-Small Cell Lung Cancer Comparing the Efficacy and Safety of Olomorasib in Combination with Standard of Care to Placebo in Combination with Standard of Care as Adjuvant Treatment after Platinum-based Chemotherapy
LUNG - Non Small Cell Cancer (NSCLC)
06/19/2025
5703
Kansas City University/2250251-1/Retrospective Data Analysis Comparing Genetic Mutations with Known Risk Factors of Common Epithelial Cancers.
SOLID TUMORS
06/18/2025
5634
Seattle Genetics/SGNB6A-001/A Phase 1 Study of SGN-B6A in Advanced Solid Tumors
SOLID TUMORS
06/13/2025
5735
Merck/V940-012/A Phase 2, Randomized, Double-Blind, Placebo- and Active-Comparator-Controlled Clinical Study of V940, also called mRNA-4157, Plus Pembrolizumab Versus Placebo Plus Pembrolizumab in Participants With First-Line Advanced Melanoma. Nickname: INTerpath-012
MELANOMA
06/13/2025
5742
Novartis/CAAA601A62301/A phase III multi-center, randomized, open-label study to evaluate the efficacy and safety of [177Lu]Lu-DOTA-TATE in patients newly diagnosed with Grade 1 and Grade 2 (Ki-67 <10%) advanced GEP-NET with high disease burden (NETTER-3)
SOLID TUMORS
05/22/2025
5670
Stemline/STML-ELA-0222/A Phase 1b/2, Open-Label Umbrella Study to Evaluate Safety and Efficacy of Elacestrant in Various Combinations in Patients with Metastatic Breast Cancer (ELEVATE)
BREAST
05/16/2025
5738
AstraZeneca/D9723C00001/A Randomized, 2-cohort, Double-blind, Placebo-controlled, Phase III Study of AZD5305 in Combination with Physician’s Choice New Hormonal Agents in Patients with HRRm and non-HRRm Metastatic Castration-Sensitive Prostate Cancer (EvoPAR-Prostate01)
PROSTATE
05/13/2025
5690
Stemline/STML-ELA-0322 (ELCIN)/ELACESTRANT in Women and Men With CDK4/6 Inhibitor-Naive Estrogen Receptor Positive, HER-2 Negative Metastatic Breast Cancer Study: An open label, multi-center, Phase 2 Study (ELCIN).
BREAST
05/07/2025
5739
OncoC4/ONC-392-001 (PRESERVE-001)/a Phase IA/IB/II, open-label, dose-escalation, and dose-expansion study of intravenous (IV) ONC-392 as a single agent and in combination with Pembrolizumab (anti-PD-1, marketed as KEYTRUDA® by Merck) in patients with advanced/metastatic solid tumors.
SOLID TUMORS
04/15/2025
5718
UA-F/2409564897/Gait and Body Composition as Clinical Biomarkers of Physical Function Decline in Individuals with Cancer
SOLID TUMORS
04/10/2025
5640
Alliance/A031704/PD-INHIBITOR (NIVOLUMAB) AND IPILIMUMAB FOLLOWED BY NIVOLUMAB VS. VEGF TKI CABOZANTINIB WITH NIVOLUMAB: A PHASE III TRIAL IN METASTATIC UNTREATED RENAL CELL CANCER [PDIGREE]
Renal
03/17/2025
5643
Pfizer/C2321003/A PHASE 3, RANDOMIZED, DOUBLE BLIND, PLACEBO CONTROLLED STUDY OF PF-06821497 WITH ENZALUTAMIDE IN METASTATIC CASTRATION RESISTANT PROSTATE CANCER
PROSTATE
03/14/2025
5654
Pfizer/Z0101001/Phase 2, Randomized, Open-label Study of Onvansertib in Combination with FOLFIRI and Bevacizumab or FOLFOX and Bevacizumab Versus FOLIRI and Bevacizumab or FOLFOX and Bevacizumab for First-line Treatment of Metastic Colorectal Cancer in Patients with KRAS or NRAS mutation
COLORECTAL
03/14/2025
5744
Novartis/CAAA617D12302/An International, Prospective, Open-label, Multi-center,Randomized Phase III Study comparing lutetium (177Lu) vipivotide tetraxetan(AAA617) versus Observation to delay castration or disease recurrence in adult male patients with prostate-specific membrane antigen (PSMA) positive Oligometastatic Prostate Cancer (OMPC)
PROSTATE
03/07/2025
5671
AstraZeneca/D8535C00001/CAMBRIA-2: A Phase III, Open-Label, Randomised Study to Assess the Efficacy and Safety of Camizestrant (AZD9833, a Next-Generation, Oral Selective Estrogen Receptor Degrader) Versus Standard Endocrine Therapy (Aromatase Inhibitor or Tamoxifen) as Adjuvant Treatment for Patients with ER+/HER2- Early Breast Cancer and an Intermediate-High or High Risk of Recurrence Who Have Completed Definitive Locoregional Treatment and Have No Evidence of Disease
BREAST
03/07/2025
5687
Tesaro/4010-01-001/A Phase 1 Dose Escalation and Cohort Expansion Study of TSR-042, an anti-PD-1 Monoclonal Antibody, in Patients with Advanced Solid Tumors
SOLID TUMORS
02/26/2025
5631
UA-F/2406543345/Investigating the feasibility of monitoring tumor response to therapy using optical spectroscopy
SOLID TUMORS
02/12/2025
5639
Bristol-Myers Squibb/CA209-76K/A Phase 3, Randomized, Double-Blind Study of Adjuvant Immunotherapy with Nivolumab versus Placebo after Complete Resection of Stage IIB/C Melanoma
MELANOMA
01/17/2025
5666
SWOG/S2209/A Phase III Randomized Trial For Newly Diagnosed Multiple Myeloma (NDMM) Patients Considered Frail Or In A Subset of Intermediate Fit Comparing Upfront Three-Drug Induction Regimens Followed by Double or Single Agent Maintenance
MULTIPLE MYELOMA
01/15/2025
5727
AstraZeneca/D926XC00001/A Phase 3 Open-label, Randomised Study of Datopotamab Deruxtecan (Dato-DXd) With or Without Durvalumab Versus Investigator’s Choice of Therapy in Patients With Stage I-III Triple-negative Breast Cancer Who Have Residual Invasive Disease in the Breast and/or Axillary Lymph Nodes at Surgical Resection Following Neoadjuvant Systemic Therapy (TROPION-Breast03)
BREAST
01/13/2025
5681
SWOG/S2312/A Phase III Study of Cabazitaxel with or without Carboplatin in Patients with Metastatic Castrate Resistant Prostate Cancer (MCRPC), Stratified by Aggressive Variant Signature
PROSTATE
01/09/2025
5731
Henlius USA Inc./HLX10-020-SCLC302/A Randomized, Double-Blind, International Multicenter, Phase III Study to Evaluate the Anti-Tumor Efficacy and Safety of HLX10 (Recombinant Humanized Anti-PD-1 Monoclonal Antibody Injection) or Placebo in Combination with Chemotherapy (Carboplatin/Cisplatin-Etoposide) and Concurrent Radiotherapy in Patients with Limited-Stage Small Cell Lung Cancer (LS-SCLC)
LUNG - Small Cell Cancer (SCLC)
12/30/2024
5695
SWOG/S2302/PRAGMATICA - LUNG: A PROSPECTIVE RANDOMIZED STUDY OF RAMUCIRUMAB (LY3009806; NSC 749128) PLUS PEMBROLIZUMAB (MK-3475; NSC 776864) VERSUS STANDARD OF CARE FOR PARTICIPANTS PREVIOUSLY TREATED WITH IMMUNOTHERAPY FOR STAGE IV OR RECURRENT NON-SMALL CELL LUNG CANCER
LUNG - Non Small Cell Cancer (NSCLC)
12/20/2024
5729
AstraZeneca/D702BC00001/A Phase III, Randomized, Double-blind, Multicenter, Global Study of Rilvegostomig or Pembrolizumab in Combination with Platinum-based Chemotherapy for the First-line Treatment of Patients with Metastatic Squamous Non-small Cell Lung Cancer Whose Tumors Express PD-L1
LUNG - Non Small Cell Cancer (NSCLC)
12/19/2024
5677
Merck/V940-001/A Phase 3, Randomized, Double-blind, Placebo- and Active-Comparator-Controlled Clinical study of Adjuvant V940 (mRNA-4157) Plus Pembrolizumab Versus Adjuvant Placebo Plus Pembrolizumab in Participants with High-risk Stage II-IV Melanoma
MELANOMA
12/13/2024
5741
Stemline/MEN2312-01/A Phase 1, First-in-Human Study of MEN2312, a KAT6 Inhibitor, as Monotherapy and in Combination in Participants with Advanced Breast Cancer, 285057
BREAST
11/26/2024
5708
AstraZeneca/D7632C00001/Phase III, Randomised, Open-label, Global Study of Datopotamab Deruxtecan (Dato-DXd) in Combination With Rilvegostomig (AZD2936) or Rilvegostomig Monotherapy Versus Pembrolizumab Monotherapy for the First-line Treatment of Participants With Locally-advanced or Metastatic Non-squamous NSCLC With High PD-L1 Expression (TC greater than/equal to 50%) and Without Actionable Genomic Alterations (TROPION-Lung10)
LUNG - Non Small Cell Cancer (NSCLC)
11/20/2024
5685
Merck/MK2870-019/A Phase 3 Randomized Open-Label Study of Adjuvant Pembrolizumab with or without MK-2870 in Resectable Stage II to IIIB (N2) NSCLC for Participants not Achieving pCR after Receiving Neoadjuvant Pembrolizumab with Platinum based Doublet Chemotherapy Followed by Surgery
LUNG - Non Small Cell Cancer (NSCLC)
11/08/2024
5712
ECOG/EA5221/A Randomized Phase III Trial of Chemo-Immunotherapy vs Immunotherapy Alone for the Vulnerable Older Adult with Advanced Non-Small Cell Lung Cancer - The ACHIEVE Study
LUNG - Non Small Cell Cancer (NSCLC)
10/18/2024
5693
Novartis/CLDK378A2X01B/An open-label, multi-center, Phase IV, roll-over study in patients with ALK positive malignancies who have completed a prior Novartis-sponsored ceritinib (LDK378) study and are judged by the investigator to benefit from continued treatment with ceritinib
LUNG - Non Small Cell Cancer (NSCLC)
10/02/2024
5672
AstraZeneca/D926NC00001/A Phase III, Randomised, Open-label, Multicentre, Global Study of Datopotamab Deruxtecan (Dato-DXd) in Combination With Durvalumab and Carboplatin Versus Pembrolizumab in Combination With Platinum-based Chemotherapy for the First-line Treatment of Patients With Locally Advanced or Metastatic NSCLC Without Actionable Genomic Alterations
LUNG - Non Small Cell Cancer (NSCLC)
08/29/2024
5679
UAMS/275695/A Phase II Clinical Trial of Candida Therapeutic Vaccine in Head and Neck Cancer Patients to Reduce Recurrence (Candin)
HEAD/NECK
07/22/2024
5632
Alliance/A032103/MODERN: AN INTEGRATED PHASE 2/3 AND PHASE 3 TRIAL OF MRD-BASED OPTIMIZATION OF ADJUVANT THERAPY IN UROTHELIAL CANCER
Urothelial
06/11/2024
5644
Revolution Medicines/RMC-6291-001/Phase 1/1b, Multicenter, Open-Label, Dose Escalation and Dose Expansion Study of RMC-6291 Monotherapy in Subjects with Advanced KRASG12C Mutant Solid Tumors
SOLID TUMORS
06/05/2024
5722
AstraZeneca/D7630C00001/A Phase III, Open-label, Randomised Study of Datopotamab Deruxtecan (Dato-DXd) With or Without Durvalumab Compared with Investigator’s Choice of Chemotherapy (Paclitaxel, Nab-paclitaxel or Gemcitabine + Carboplatin) in Combination With Pembrolizumab in Patients with PD-L1 Positive Locally Recurrent Inoperable or Metastatic Triple-negative Breast Cancer (TROPION-Breast05)
BREAST
06/04/2024
5684
AstraZeneca/D967RC00001/A Phase 3 Open-label Trial of Neoadjuvant Trastuzumab Deruxtecan (T-DXd) Monotherapy or T-DXd followed by THP Compared to ddAC-THP in Participants with High-risk HER2-positive Early-stage Breast Cancer (DESTINY-Breast11)
BREAST
03/29/2024
5682
UAMS/HOG Care/Analyzing Breast Cancer Incidence and Compliance Rates Among Patients in the Highlands Oncology CARE Clinic Database
BREAST
02/26/2024
5698
Alliance/A012103/optimICE-pCR: DE-ESCALATION OF THERAPY IN EARLY-STAGE TNBC PATIENTS WHO ACHIEVE PCR AFTER NEOADJUVANT CHEMOTHERAPY WITH CHECKPOINT INHIBITOR THERAPY
BREAST
08/15/2023
5642
AstraZeneca/D967UC00001/Phase III Study of Trastuzumab Deruxtecan (T-DXd) with or without Pertuzumab versus Taxane, Trastuzumab and Pertuzumab in HER2-positive, First-line Metastatic Breast Cancer (DESTINY-Breast09)
BREAST
04/28/2023
5683
Eli Lilly/J2J-MC-JZLA EMBER/EMBER: A Phase 1a/1b Study of LY3484356 Administered as Monotherapy and in Combination with Anticancer Therapies for Patients with ER+ Locally Advanced or Metastatic Breast Cancer and Other Select Non-Breast Cancers
BREAST
03/01/2023
5700
Merck/MK-1026-003/A Phase 2 Study to Evaluate the Efficacy and Safety of MK-1026 in Participants with Hematologic Malignancies
Lymphoma
02/02/2023
5710
Ascentage/APG5918XG101/A Phase I Study of Safety, Pharmacokinetic and Efficacy of Orally Administered APG-5918 in Patients with Advanced Solid Tumors or Hematologic Malignancies
SOLID TUMORS
10/13/2022
5648
Novartis/CLEE011A2412B/A post-trial access roll-over study to allow access to ribociclib (LEE011) for patients who are on ribociclib treatment in Novartis-sponsored study
BREAST
09/22/2022
5673
SWOG/S1404/A PHASE III RANDOMIZED TRIAL COMPARING PHYSICIAN/PATIENT CHOICE OF EITHER HIGH DOSE INTERFERON OR IPILIMUMAB TO MK-3475 (PEMBROLIZUMAB) IN PATIENTS WITH HIGH RISK RESECTED MELANOMA
MELANOMA
08/01/2020
5724
Eli Lilly/I3Y-MC-JPCF/A Randomized, Open-Label, Phase 3 Study of Abemaciclib Combined with Standard Adjuvant Endocrine Therapy versus Standard Adjuvant Endocrine Therapy Alone in Patients with High Risk, Node Positive, Early Stage, Hormone Receptor Positive, Human Epidermal Receptor 2 Negative, Breast Cancer
BREAST
08/14/2019
5699
Alliance/A011106/Alternate approaches for clinical stage II or III Estrogen Receptor positive breast cancer NeoAdjuvant Treatment (ALTERNATE) in postmenopausal women: A Phase III Study
BREAST
07/05/2019
5641
SWOG/S1207/Phase III Randomized, Placebo-Controlled Clinical Trial Evaluating the Use of Adjuvant Endocrine Therapy +/- One Year of Everolimus in Patients with High-Risk, Hormone Receptor-Positive and HER2/neu Negative Breast Cancer. e3 Breast Cancer Study- evaluating everolimus with endocrine therapy
BREAST
05/01/2019
5723
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